UCSF

Shoichet Laboratory

Ampc inhibitors


These compounds inhibit AmpC competitvely:

NameSmile stringKi [ÁM]PDBReference
3-(Benzothiazol-2-ylsulfanyl)-propionic acidc1cccc2nc(sc12)SCCC(=O)O646.0-Powers et. al., 2002
Sodium; 3-(benzothiazol-2-ylsulfanyl)-propane-1-sulfonateC(CS(=O)(=O)O)CSc1sc2ccccc2n1318.0-Powers et. al., 2002
3-(4-Sulfamoyl-phenylsulfamoyl)-thiophene-2-carboxylic acids1c(C(=O)O)c(S(=O)(Nc2ccc(S(=O)(=O)N)cc2)=O)cc193.0-Graves et. al., 2005
3-(2-Piperidin-1-yl-phenylsulfamoyl)-thiophene-2-carboxylic acids1ccc(S(=O)(Nc2c(N3CCCCC3)cccc2)=O)c1C(=O)O14.0-Powers et. al., 2002
2,5-Dimethyl-4-(thiophen-2-ylsulfamoyl)-furan-3-carboxylic acid/ Analog(Powers)s1cccc1NS(c2c(C(=O)O)c(oc2C)C)(=O)=O64.0-Powers et. al., 2002
3-(4-Chloro-phenylsulfamoyl)-thiophene-2-carboxylic acids1c(C(=O)O)c(S(=O)(Nc2ccc(Cl)cc2)=O)cc126.0-Powers et. al., 2002
2-Methyl-4-(toluene-4-sulfonylamino)-thiophene-3-carboxylic acids1c(cc(C(=O)O)c1C)NS(c2ccc(C)cc2)(=O)=O60.0-Powers et. al., 2002
3-(4-Chloro-benzenesulfonylamino)-thiophene-2-carboxylic acids1ccc(NS(c2ccc(cc2)Cl)(=O)=O)c1C(=O)O310.0-Tondi et. al., 2005
2-(4-Chloro-phenylsulfamoyl)-benzoic acidS(=O)(c1c(C(=O)O)cccc1)(Nc2ccc(Cl)cc2)=O45.0-Tondi et. al., 2005
N-(4-Chloro-phenyl)-phthalamic acidC(=O)(c1c(cccc1)C(=O)O)Nc2ccc(Cl)cc2340.0-Tondi et. al., 2005
3-Benzylsulfamoyl-thiophene-2-carboxylic acidS(=O)(c1c(C(=O)O)scc1)(NCc2ccccc2)=O26.0-Tondi et. al., 2005
3-(4-Bromo-phenylsulfamoyl)-thiophene-2-carboxylic acidS(=O)(=O)(c1c(C(=O)O)scc1)Nc2ccc(Br)cc231.0-Tondi et. al., 2005
3-(4-Carboxy-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1ccc(C(=O)O)cc1)(c2ccsc2C(=O)[O-])(=O)=O1.1-Tondi et. al., 2005
3-(3-Carboxy-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1cccc(c1)C(=O)O)(c2ccsc2C(=O)[O-])(=O)=O1.7-Tondi et. al., 2005
3-(4-Carboxy-3-chloro-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1ccc(C(=O)O)c(c1)Cl)(c2ccsc2C(=O)[O-])(=O)=O1.9-Tondi et. al., 2005
3-(4-Carboxy-2-hydroxy-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1c(O)cc(C(=O)O)cc1)(c2c(scc2)C(=O)O)(=O)=O1.0-Tondi et. al., 2005
3-(3-Nitro-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1cc(N(=O)=O)ccc1)(c2c(scc2)C(=O)O)(=O)=O14.0-Tondi et. al., 2005
3-(2-Nitro-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1c(N(=O)=O)cccc1)(c2c(scc2)C(=O)O)(=O)=O10.0-Tondi et. al., 2005
3-(3,4-Dichloro-phenylsulfamoyl)-thiophene-2-carboxylic acidS(Nc1cc(Cl)c(Cl)cc1)(c2c(scc2)C(=O)O)(=O)=O8.7-Tondi et. al., 2005
3-(3,4-Dichloro-phenylsulfamoyl)-thiophene-2-carboxylic acid methyl esterS(Nc1cc(Cl)c(Cl)cc1)(c2c(scc2)C(OC)=O)(=O)=O170.0-Tondi et. al., 2005
3-(3-Nitro-benzenesulfonylamino)-thiophene-2-carboxylic acids1c(C(=O)O)c(cc1)NS(=O)(=O)c2cccc(N(=O)=O)c2250.0-Tondi et. al., 2005

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